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| Rossato,Janine I.; Zinn,Carolina G.; Furini,Cristiane; Bevilaqua,Lia R.M.; Medina,Jorge H.; Cammarota,Martín; Izquierdo,Iván. |
| Two major memory systems have been recognized over the years (Squire 1987): the declarative memory system, which is under the control of the hippocampus and related temporal lobe structures, and the procedural or habit memory system, which is under the control of the striatum and its connections. Most if not all learning tasks studied in animals, however, involve either the performance or the suppression of movement; this, if learned well, may be viewed as having become a habit. It is agreed that memory rules change from their first association to those that take place when the task is mastered. Does this change of rules involve a switch from one memory system to another? Here we will comment on: 1) reversal learning in the Morris water maze (MWM), in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hippocampus; Striatum; Declarative memory; Procedural memory; Habits; Learning. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000300011 |
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| Izquierdo,Iván; Cammarota,Martín; Silva,Weber C. Da; Bevilaqua,Lia R.M.; Rossato,Janine I.; Bonini,Juliana S.; Mello,Pamela; Benetti,Fernando; Costa,Jaderson C.; Medina,Jorge H.. |
| Long-term potentiation (LTP) is the enhancement of postsynaptic responses for hours, days or weeks following the brief repetitive afferent stimulation of presynaptic afferents. It has been proposed many times over the last 30 years to be the basis of long-term memory. Several recent findings finally supported this hypothesis: a) memory formation of one-trial avoidance learning depends on a series of molecular steps in the CA1 region of the hippocampus almost identical to those of LTP in the same region; b)hippocampal LTP in this region accompanies memory formation of that task and of another similar task. However, CA1 LTP and the accompanying memory processes can be dissociated, and in addition plastic events in several other brain regions(amygdala,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Long-term potentiation; Hippocampus; Declarative memory; Aversive memory. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100007 |
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| Cammarota,Martín; Barros,Daniela M.; Vianna,Mónica R.M.; Bevilaqua,Lia R.M.; Coitinho,Adriana; Szapiro,Germán; Izquierdo,Luciana A.; Medina,Jorge H.; Izquierdo,Iván. |
| Memory is measured by measuring retrieval. Retrieval is often triggered by the conditioned stimulus (CS); however, as known since Pavlov, presentation of the CS alone generates extinction. One-trial avoidance (IA) is a much used conditioned fear paradigm in which the CS is the safe part of a training apparatus, the unconditioned stimulus (US) is a footshock and the conditioned response is to stay in the safe area. In IA, retrieval is measured without the US, as latency to step-down from the safe area (i.e., a platform). Extinction is installed at the moment of the first unreinforced test session, as clearly shown by the fact that many drugs, including PKA, ERK and protein synthesis inhibitors as well as NMDA receptor antagonists, hinder extinction when... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Memory; Retrieval; Extinction; Reconsolidation; Inhibitory avoidance. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000300011 |
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